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Validation of models to study aerosol deposition in human nasal cavities
Publication: Pharm Res, 2014, janv, 31(1), 228-37. Published online 09/25/2013.
Authors : Sandrine Le Guellec & Deborah Le Pennec & Stephane Gatier & Lara Leclerc & Maria Cabrera & Jeremie Pourchez & Patrice Diot & Gregory Reychler & Laurent Pitance & Marc Durand & François Jamar & Laurent Vecellio
Purpose: Intranasal deposition of aerosols is often studied using in vitro nasal cavity models. However, the relevance of these models to predict in vivo human deposition has not been validated. This study compared in vivo nasal aerosol deposition and in vitro deposition in a human plastinated head model (NC1) and its replica constructed from CT-scan (NC2).
Methods: Two nebulizers (Atomisor Sonique® and Easynose®) were used to administer a 5.6 μmaerosol of 99mTc-DTPA to seven healthy volunteers and to the nasalmodels. Aerosol deposition was quantified by γ scintigraphy in the nasal, upper nasal cavity and maxillary sinus (MS) regions. The distribution of aerosol deposition was determined along three nasal cavity axes (x, y and z).
Results: There was no significant difference regarding aerosol deposition between the volunteers and NC1. Aerosol deposition was significantly lower in NC2 than in volunteers regarding nasal region (p)
Conclusions: In conclusion, nasal models can be used to predict aerosol deposition produced by nebulizers, but their performance depends on their design.