Reynard O, Iampietro M, Dumont C, Le Guellec S, Durand S, Moroso M, Brisebard E, Dhondt KP, Pelissier R, Mathieu C, Cabrera M, Le Pennec D, Amurri L, Alabi C, Cardinaud S, Porotto M, Moscona A, Vecellio L, Horvat B. Development of nebulized inhalation delivery for fusion-inhibitory lipopeptides to protect non-human primates against Nipah-Bangladesh infection. Antiviral Res. 2025 Mar;235:106095. doi: 10.1016/j.antiviral.2025.106095. Epub 2025 Jan 25. PMID: 39870114. https://pubmed.ncbi.nlm.nih.gov/39870114/
Pasteur M, Arsouze G, Ilango G, Le Pennec D, Kulker D, Heyraud A, Cottier JP, Aussedat C, Heuzé-Vourc'h N, Hervé V, Le Guellec S. Characterization of anatomical variations of the nasal cavity in a subset of European patients and their impact on intranasal drug delivery. Int J Pharm. 2024 Dec 25;667(Pt A):124851. doi: 10.1016/j.ijpharm.2024.124851. Epub 2024 Oct 26. PMID: 39490788. https://pubmed.ncbi.nlm.nih.gov/39490788/
Reynard O, Montharu J, Iampietro M, Gonzalez C, Le Guellec S, Horvat B, Vecellio L. Setup of Aerosol Delivery System to Prevent Measles Virus Infection in Nonhuman Primate Model. Methods Mol Biol. 2024;2808:167-175. doi: 10.1007/978-1-0716-3870-5_13. PMID: 38743370. https://pubmed.ncbi.nlm.nih.gov/38743370/
Publications
Aérodrug contribue à la publications d'articles scientifiques, de revues et d'autres supports (presse, magazines, posters scientifiques, communications dans des congrès nationaux et internationaux, ...).
2025/2024
Reynard O, Montharu J, Iampietro M, Gonzalez C, Le Guellec S, Horvat B, Vecellio L. Setup of Aerosol Delivery System to Prevent Measles Virus Infection in Nonhuman Primate Model. Methods Mol Biol. 2024;2808:167-175. doi: 10.1007/978-1-0716-3870-5_13. PMID: 38743370. https://pubmed.ncbi.nlm.nih.gov/38743370/
2023/2022
Cabrera M, Le Pennec D, Le Guellec S, Pardessus J, Ehrmann S, MacLoughlin R, Heuzé-Vourc'h N, Vecellio L. Influence of mesh nebulizer characteristics on aerosol delivery in non-human primates. Eur J Pharm Sci. 2023 Dec 1;191:106606. doi: 10.1016/j.ejps.2023.106606. Epub 2023 Oct 11. PMID: 37832856. https://pubmed.ncbi.nlm.nih.gov/37832856/
Le Guellec S, Pardessus J, Bodier-Montagutelli E, L'Hostis G, Dalloneau E, Piel D, Samaï HC, Guillon A, Mujic E, Guillot-Combe E, Ehrmann S, Morello E, Gabard J, Heuzé-Vourc'h N, Fevre C, Vecellio L. Administration of Bacteriophages via Nebulization during Mechanical Ventilation: In Vitro Study and Lung Deposition in Macaques. Viruses. 2023 Feb 22;15(3):602. doi: 10.3390/v15030602. PMID: 36992312; PMCID: PMC10051375. https://pubmed.ncbi.nlm.nih.gov/36992312/
Reynard O, Gonzalez C, Dumont C, Iampietro M, Ferren M, Le Guellec S, Laurie L, Mathieu C, Carpentier G, Roseau G, Bovier FT, Zhu Y, Le Pennec D, Montharu J, Addetia A, Greninger AL, Alabi CA, Brisebard E, Moscona A, Vecellio L, Porotto M, Horvat B. Nebulized fusion inhibitory peptide protects cynomolgus macaques from measles virus infection. Nat Commun. 2022 Oct 28;13(1):6439. doi: 10.1038/s41467-022-33832-6. PMID: 36307480; PMCID: PMC9616412. https://pubmed.ncbi.nlm.nih.gov/36307480/
Le Guellec S, Pardessus J, Bodier-Montagutelli E, L'Hostis G, Dalloneau E, Piel D, Samaï HC, Guillon A, Mujic E, Guillot-Combe E, Ehrmann S, Morello E, Gabard J, Heuzé-Vourc'h N, Fevre C, Vecellio L. Administration of Bacteriophages via Nebulization during Mechanical Ventilation: In Vitro Study and Lung Deposition in Macaques. Viruses. 2023 Feb 22;15(3):602. doi: 10.3390/v15030602. PMID: 36992312; PMCID: PMC10051375. https://pubmed.ncbi.nlm.nih.gov/36992312/
Reynard O, Gonzalez C, Dumont C, Iampietro M, Ferren M, Le Guellec S, Laurie L, Mathieu C, Carpentier G, Roseau G, Bovier FT, Zhu Y, Le Pennec D, Montharu J, Addetia A, Greninger AL, Alabi CA, Brisebard E, Moscona A, Vecellio L, Porotto M, Horvat B. Nebulized fusion inhibitory peptide protects cynomolgus macaques from measles virus infection. Nat Commun. 2022 Oct 28;13(1):6439. doi: 10.1038/s41467-022-33832-6. PMID: 36307480; PMCID: PMC9616412. https://pubmed.ncbi.nlm.nih.gov/36307480/
2021/2020
Guillon A, Pardessus J, L'Hostis G, Fevre C, Barc C, Dalloneau E, Jouan Y, Bodier-Montagutelli E, Perez Y, Thorey C, Mereghetti L, Cabrera M, Riou M, Vecellio L, Le Guellec S, Heuzé-Vourc'h N. Inhaled bacteriophage therapy in a porcine model of pneumonia caused by Pseudomonas aeruginosa during mechanical ventilation. Br J Pharmacol. 2021 Sep;178(18):3829-3842. doi: 10.1111/bph.15526. Epub 2021 Jul 9. PMID: 33974271. https://pubmed.ncbi.nlm.nih.gov/33974271/
Le Guellec S, Ehrmann S, Vecellio L. In vitro - in vivo correlation of intranasal drug deposition. Adv Drug Deliv Rev. 2021 Mar; 170:340-352. doi: 10.1016/j.addr.2020.09.002. Epub 2020 Sep 10. PMID: 32918968. https://pubmed.ncbi.nlm.nih.gov/32918968/
Le Guellec S, Allimonnier L, Heuzé-Vourc'h N, Cabrera M, Ossant F, Pourchez J, Vecellio L, Plantier L. Low-Frequency Intrapulmonary Percussive Ventilation Increases Aerosol Penetration in a 2-Compartment Physical Model of Fibrotic Lung Disease. Front Bioeng Biotechnol. 2020 Aug 28;8:1022. doi: 10.3389/fbioe.2020.01022. PMID: 32984287; PMCID: PMC7483496. https://pubmed.ncbi.nlm.nih.gov/32984287/
Le Guellec S, Ehrmann S, Vecellio L. In vitro - in vivo correlation of intranasal drug deposition. Adv Drug Deliv Rev. 2021 Mar; 170:340-352. doi: 10.1016/j.addr.2020.09.002. Epub 2020 Sep 10. PMID: 32918968. https://pubmed.ncbi.nlm.nih.gov/32918968/
Le Guellec S, Allimonnier L, Heuzé-Vourc'h N, Cabrera M, Ossant F, Pourchez J, Vecellio L, Plantier L. Low-Frequency Intrapulmonary Percussive Ventilation Increases Aerosol Penetration in a 2-Compartment Physical Model of Fibrotic Lung Disease. Front Bioeng Biotechnol. 2020 Aug 28;8:1022. doi: 10.3389/fbioe.2020.01022. PMID: 32984287; PMCID: PMC7483496. https://pubmed.ncbi.nlm.nih.gov/32984287/
2017/2016
Guillon A, Sécher T, Dailey LA, Vecellio L, de Monte M, Si-Tahar M, Diot P, Page CP, Heuzé-Vourc'h N. Insights on animal models to investigate inhalation therapy: Relevance for biotherapeutics. Int J Pharm. 2018 Jan 30;536(1):116-126. doi: 10.1016/j.ijpharm.2017.11.049. Epub 2017 Nov 24. PMID: 29180257. https://pubmed.ncbi.nlm.nih.gov/29180257/
Baravalle-Einaudi M, Dufeu N, Dupont C, Vecellio L, Delaisi B, Carsin A, Dubus JC; GRAM (Aerosols and Cystic Fibrosis Workgroup of the French Cystic Fibrosis Society). Vibrating-mesh nebulizer maintenance by CF patients: Results from a French survey. Pulm Pharmacol Ther. 2017 Jun;44:57-60. doi: 10.1016/j.pupt.2017.03.011. Epub 2017 Mar 15. PMID: 28315491. https://pubmed.ncbi.nlm.nih.gov/28315491/
Bodier-Montagutelli E, Morello E, L'Hostis G, Guillon A, Dalloneau E, Respaud R, Pallaoro N, Blois H, Vecellio L, Gabard J, Heuzé-Vourc'h N. Inhaled phage therapy: a promising and challenging approach to treat bacterial respiratory infections. Expert Opin Drug Deliv. 2017 Aug;14(8):959-972. doi: 10.1080/17425247.2017.1252329. Epub 2016 Nov 10. PMID: 27776446. https://pubmed.ncbi.nlm.nih.gov/27776446/
Réminiac F, Vecellio L, Loughlin RM, Le Pennec D, Cabrera M, Vourc'h NH, Fink JB, Ehrmann S. Nasal high flow nebulization in infants and toddlers: An in vitro and in vivo scintigraphic study. Pediatr Pulmonol. 2017 Mar;52(3):337-344. doi: 10.1002/ppul.23509. Epub 2016 Jul 8. PMID: 27392199. https://pubmed.ncbi.nlm.nih.gov/27392199/
Nébulisation en rhinologie : les erreurs à éviter, dans : Le dossier Rhinologie / Les réalités pédiatriques # 199_Février/Mars 2016. http://www.realites-pediatriques.com/wp-content/uploads/sites/3/2016/05/RP_199_Pruliere-Escabasse.pdf
Guillon A, Vecellio L, de Monte M. Pulmonary Delivery of Dry Powders During Invasive Mechanical Ventilation: Innovations Are Required. J Aerosol Med Pulm Drug Deliv. 2016 Apr;29(2):215-6. doi: 10.1089/jamp.2015.1248. Epub 2015 Dec 1. PMID: 26625305. https://pubmed.ncbi.nlm.nih.gov/26625305/
Baravalle-Einaudi M, Dufeu N, Dupont C, Vecellio L, Delaisi B, Carsin A, Dubus JC; GRAM (Aerosols and Cystic Fibrosis Workgroup of the French Cystic Fibrosis Society). Vibrating-mesh nebulizer maintenance by CF patients: Results from a French survey. Pulm Pharmacol Ther. 2017 Jun;44:57-60. doi: 10.1016/j.pupt.2017.03.011. Epub 2017 Mar 15. PMID: 28315491. https://pubmed.ncbi.nlm.nih.gov/28315491/
Bodier-Montagutelli E, Morello E, L'Hostis G, Guillon A, Dalloneau E, Respaud R, Pallaoro N, Blois H, Vecellio L, Gabard J, Heuzé-Vourc'h N. Inhaled phage therapy: a promising and challenging approach to treat bacterial respiratory infections. Expert Opin Drug Deliv. 2017 Aug;14(8):959-972. doi: 10.1080/17425247.2017.1252329. Epub 2016 Nov 10. PMID: 27776446. https://pubmed.ncbi.nlm.nih.gov/27776446/
Réminiac F, Vecellio L, Loughlin RM, Le Pennec D, Cabrera M, Vourc'h NH, Fink JB, Ehrmann S. Nasal high flow nebulization in infants and toddlers: An in vitro and in vivo scintigraphic study. Pediatr Pulmonol. 2017 Mar;52(3):337-344. doi: 10.1002/ppul.23509. Epub 2016 Jul 8. PMID: 27392199. https://pubmed.ncbi.nlm.nih.gov/27392199/
Nébulisation en rhinologie : les erreurs à éviter, dans : Le dossier Rhinologie / Les réalités pédiatriques # 199_Février/Mars 2016. http://www.realites-pediatriques.com/wp-content/uploads/sites/3/2016/05/RP_199_Pruliere-Escabasse.pdf
Guillon A, Vecellio L, de Monte M. Pulmonary Delivery of Dry Powders During Invasive Mechanical Ventilation: Innovations Are Required. J Aerosol Med Pulm Drug Deliv. 2016 Apr;29(2):215-6. doi: 10.1089/jamp.2015.1248. Epub 2015 Dec 1. PMID: 26625305. https://pubmed.ncbi.nlm.nih.gov/26625305/
2015/2014
Reychler G, Colbrant C, Huart C, Le Guellec S, Vecellio L, Liistro G, Rombaux P. Effect of three-drug delivery modalities on olfactory function in chronic sinusitis. Laryngoscope. 2015 Mar;125(3):549-55. doi: 10.1002/lary.24937. Epub 2014 Sep 16. PMID: 25224684. https://pubmed.ncbi.nlm.nih.gov/25224684/
Benattia A, Cavaillon P, Gachelin E, Devillier P, Vecellio L, Williams G, Dubus JC. Traitements inhalés : critères de choix des dispositifs, absorption systémique des médicaments par voie inhalée et récepteurs pulmonaires à l'amertume [Inhaled treatments: Choice of devices, systemic absorption of inhaled drugs and bitter taste receptors in the respiratory tract]. Rev Mal Respir. 2015 Oct;32(8):791-9. French. doi: 10.1016/j.rmr.2014.06.032. Epub 2015 Oct 16. PMID: 26480888. https://www.sciencedirect.com/science/article/pii/S0761842514012571
Gachelin E, Vecellio L, Dubus JC; Aerosol Group of the French Pneumology Society (GAT); Paediatric Respiratory and Allergology Society (SP2A). Évaluation critique des chambres d'inhalation commercialisées en France [Critical evaluation of inhalation spacer devices available in France]. Rev Mal Respir. 2015 Sep;32(7):672-81. French. doi: 10.1016/j.rmr.2015.01.008. Epub 2015 Jul 8. PMID: 26163392. https://www.sciencedirect.com/science/article/pii/S0761842515002211
J.-C. Dubus, E. Gachelin, M. Baravalle-Einaudi, A. Carsin, L. Vecellio. Asthme: la jungle des chambres d'inhalation. Archives de pédiatrie, Vol 22, Issue 5, Supplement 1, May 2015, Pages 157-158. https://www.sciencedirect.com/science/article/pii/S0929693X15300786
Desoubeaux G, Bernard MC, Gros V, Sarradin P, Perrodeau E, Vecellio L, Piscopo A, Chandenier J, Bernard L. Testing an innovative device against airborne Aspergillus contamination. Med Mycol. 2014 Aug;52(6):584-90. doi: 10.1093/mmy/myu011. Epub 2014 Jun 25. PMID: 24965945.
Laouini A, Andrieu V, Vecellio L, Fessi H, Charcosset C. Characterization of different vitamin E carriers intended for pulmonary drug delivery. Int J Pharm. 2014 Aug 25;471(1-2):385-90. doi: 10.1016/j.ijpharm.2014.05.062. Epub 2014 Jun 2. PMID: 24939617.
Albuquerque-Silva I, Vecellio L, Durand M, Avet J, Le Pennec D, de Monte M, Montharu J, Diot P, Cottier M, Dubois F, Pourchez J. Particle deposition in a child respiratory tract model: in vivo regional deposition of fine and ultrafine aerosols in baboons. PLoS One. 2014 Apr 30;9(4):e95456. doi: 10.1371/journal.pone.0095456. PMID: 24787744; PMCID: PMC4005734.
Leclerc L, Pourchez J, Aubert G, Leguellec S, Vecellio L, Cottier M, Durand M. Impact of airborne particle size, acoustic airflow and breathing pattern on delivery of nebulized antibiotic into the maxillary sinuses using a realistic human nasal replica. Pharm Res. 2014 Sep;31(9):2335-43. doi: 10.1007/s11095-014-1330-6. Epub 2014 Mar 4. PMID: 24590882. https://pubmed.ncbi.nlm.nih.gov/24590882/
Leclerc L, Pourchez J, Prevot N, Vecellio L, Le Guellec S, Cottier M, Durand M. Assessing sinus aerosol deposition: benefits of SPECT-CT imaging. Int J Pharm. 2014 Feb 28;462(1-2):135-41. doi: 10.1016/j.ijpharm.2013.12.032. Epub 2013 Dec 26. PMID: 24374606. https://pubmed.ncbi.nlm.nih.gov/24374606/
Vecellio L, Le Guellec S, Chantrel G. Sonic nebulization in rhinology. On drug delivery, Pulmonary and nasal delivery, 2014, 53:34-37. Vecellio & Le Guellec-ODD 2015
Le Guellec S, Le Pennec D, Gatier S, Leclerc L, Cabrera M, Pourchez J, Diot P, Reychler G, Pitance L, Durand M, Jamar F, Vecellio L. Validation of anatomical models to study aerosol deposition in human nasal cavities. Pharm Res. 2014 Jan;31(1):228-37. doi: 10.1007/s11095-013-1157-6. Epub 2013 Sep 25. PMID: 24065586; PMCID: PMC3889297. https://pubmed.ncbi.nlm.nih.gov/24065586/
Dubus JC, Bassinet L, Chedevergne F, Delaisi B, Desmazes-Dufeu N, Reychler G, Vecellio L; GRAM (Groupe aérosols et mucoviscidose de la Société française de mucoviscidose). Mucoviscidose et traitements inhalés: quoi de neuf en 2013? [Inhaled treatments in cystic fibrosis: what's new in 2013?]. Rev Mal Respir. 2014 Apr;31(4):336-46. French. doi: 10.1016/j.rmr.2013.12.001. Epub 2014 Jan 4. PMID: 24750953.
Lelong N, Junqua-Moullet A, Diot P, Vecellio L. Comparison of laser diffraction measurements by Mastersizer X and Spraytec to characterize droplet size distribution of medical liquid aerosols. J Aerosol Med Pulm Drug Deliv. 2014 Apr;27(2):94-102. doi: 10.1089/jamp.2012.1030. Epub 2013 May 13. PMID: 23668547.
Marchand D., Parent C., Respaud R., Guillemain J., Pelat T., Thullier P., Vecellio L., Heuze-Vourc’h N. Administration d’anticorps anti-ricine par voie aérosol & développement d’un générateur d’aérosol et d’une formulation pour le dépôt alvéolaire de l’anticorps, Rev Mal Respir. 2014 Apr;31(7):667-668.
Recommendations ORL 2014 Work group of the French Society of Otorhinolaryngology (SFORL). Consensus document for prescription of nebulization in rhinology. Eur Ann Otorhinolaryngol Head Neck Dis. 2014 Dec;131(6):371-374. doi: 10.1016/j.anorl.2014.07.004. PMID: 25456242. https://www.orlfrance.org/wp-content/uploads/2017/06/Recommandation_nebulisation_2014.pdf
Benattia A, Cavaillon P, Gachelin E, Devillier P, Vecellio L, Williams G, Dubus JC. Traitements inhalés : critères de choix des dispositifs, absorption systémique des médicaments par voie inhalée et récepteurs pulmonaires à l'amertume [Inhaled treatments: Choice of devices, systemic absorption of inhaled drugs and bitter taste receptors in the respiratory tract]. Rev Mal Respir. 2015 Oct;32(8):791-9. French. doi: 10.1016/j.rmr.2014.06.032. Epub 2015 Oct 16. PMID: 26480888. https://www.sciencedirect.com/science/article/pii/S0761842514012571
Gachelin E, Vecellio L, Dubus JC; Aerosol Group of the French Pneumology Society (GAT); Paediatric Respiratory and Allergology Society (SP2A). Évaluation critique des chambres d'inhalation commercialisées en France [Critical evaluation of inhalation spacer devices available in France]. Rev Mal Respir. 2015 Sep;32(7):672-81. French. doi: 10.1016/j.rmr.2015.01.008. Epub 2015 Jul 8. PMID: 26163392. https://www.sciencedirect.com/science/article/pii/S0761842515002211
J.-C. Dubus, E. Gachelin, M. Baravalle-Einaudi, A. Carsin, L. Vecellio. Asthme: la jungle des chambres d'inhalation. Archives de pédiatrie, Vol 22, Issue 5, Supplement 1, May 2015, Pages 157-158. https://www.sciencedirect.com/science/article/pii/S0929693X15300786
Desoubeaux G, Bernard MC, Gros V, Sarradin P, Perrodeau E, Vecellio L, Piscopo A, Chandenier J, Bernard L. Testing an innovative device against airborne Aspergillus contamination. Med Mycol. 2014 Aug;52(6):584-90. doi: 10.1093/mmy/myu011. Epub 2014 Jun 25. PMID: 24965945.
Laouini A, Andrieu V, Vecellio L, Fessi H, Charcosset C. Characterization of different vitamin E carriers intended for pulmonary drug delivery. Int J Pharm. 2014 Aug 25;471(1-2):385-90. doi: 10.1016/j.ijpharm.2014.05.062. Epub 2014 Jun 2. PMID: 24939617.
Albuquerque-Silva I, Vecellio L, Durand M, Avet J, Le Pennec D, de Monte M, Montharu J, Diot P, Cottier M, Dubois F, Pourchez J. Particle deposition in a child respiratory tract model: in vivo regional deposition of fine and ultrafine aerosols in baboons. PLoS One. 2014 Apr 30;9(4):e95456. doi: 10.1371/journal.pone.0095456. PMID: 24787744; PMCID: PMC4005734.
Leclerc L, Pourchez J, Aubert G, Leguellec S, Vecellio L, Cottier M, Durand M. Impact of airborne particle size, acoustic airflow and breathing pattern on delivery of nebulized antibiotic into the maxillary sinuses using a realistic human nasal replica. Pharm Res. 2014 Sep;31(9):2335-43. doi: 10.1007/s11095-014-1330-6. Epub 2014 Mar 4. PMID: 24590882. https://pubmed.ncbi.nlm.nih.gov/24590882/
Leclerc L, Pourchez J, Prevot N, Vecellio L, Le Guellec S, Cottier M, Durand M. Assessing sinus aerosol deposition: benefits of SPECT-CT imaging. Int J Pharm. 2014 Feb 28;462(1-2):135-41. doi: 10.1016/j.ijpharm.2013.12.032. Epub 2013 Dec 26. PMID: 24374606. https://pubmed.ncbi.nlm.nih.gov/24374606/
Vecellio L, Le Guellec S, Chantrel G. Sonic nebulization in rhinology. On drug delivery, Pulmonary and nasal delivery, 2014, 53:34-37. Vecellio & Le Guellec-ODD 2015
Le Guellec S, Le Pennec D, Gatier S, Leclerc L, Cabrera M, Pourchez J, Diot P, Reychler G, Pitance L, Durand M, Jamar F, Vecellio L. Validation of anatomical models to study aerosol deposition in human nasal cavities. Pharm Res. 2014 Jan;31(1):228-37. doi: 10.1007/s11095-013-1157-6. Epub 2013 Sep 25. PMID: 24065586; PMCID: PMC3889297. https://pubmed.ncbi.nlm.nih.gov/24065586/
Dubus JC, Bassinet L, Chedevergne F, Delaisi B, Desmazes-Dufeu N, Reychler G, Vecellio L; GRAM (Groupe aérosols et mucoviscidose de la Société française de mucoviscidose). Mucoviscidose et traitements inhalés: quoi de neuf en 2013? [Inhaled treatments in cystic fibrosis: what's new in 2013?]. Rev Mal Respir. 2014 Apr;31(4):336-46. French. doi: 10.1016/j.rmr.2013.12.001. Epub 2014 Jan 4. PMID: 24750953.
Lelong N, Junqua-Moullet A, Diot P, Vecellio L. Comparison of laser diffraction measurements by Mastersizer X and Spraytec to characterize droplet size distribution of medical liquid aerosols. J Aerosol Med Pulm Drug Deliv. 2014 Apr;27(2):94-102. doi: 10.1089/jamp.2012.1030. Epub 2013 May 13. PMID: 23668547.
Marchand D., Parent C., Respaud R., Guillemain J., Pelat T., Thullier P., Vecellio L., Heuze-Vourc’h N. Administration d’anticorps anti-ricine par voie aérosol & développement d’un générateur d’aérosol et d’une formulation pour le dépôt alvéolaire de l’anticorps, Rev Mal Respir. 2014 Apr;31(7):667-668.
Recommendations ORL 2014 Work group of the French Society of Otorhinolaryngology (SFORL). Consensus document for prescription of nebulization in rhinology. Eur Ann Otorhinolaryngol Head Neck Dis. 2014 Dec;131(6):371-374. doi: 10.1016/j.anorl.2014.07.004. PMID: 25456242. https://www.orlfrance.org/wp-content/uploads/2017/06/Recommandation_nebulisation_2014.pdf