Impact of MMAD, accoustic airflow and breathing paterns on intrasinus drug deposition in a realistic nasal cast
ERS/ISIAN (25th congress of European Rhinology Society & 32th International Symposium of Infection & Allergy of the Nose 2014), Amsterdam (Pays Bas).
Auteurs : Leclerc L, Pourchez J, Aubert G, Vecellio L, Le Guellec S, Cottier M, Durand M.
Objectives: Targeting delivery of nebulized drug into the maxillary sinuses is a main issue to improve clinical outcomes in patients with sinus disorders. To enhance the drug deposition in sinuses, the impact of 100 Hertz (Hz) acoustic airflow, MMAD (9μm, 3μm, 500nm and 250nm) and breathing pattern (no breathing, 10 breaths/min I/E=1 TV=750mL; 15 breaths/min I/E=40/60 TV=500mL) were investigated using a realistic nasal cast.
Methods: After segmenting airways from high resolution computed tomography scan images, rapid prototyping technology was employed to build stereolithographic resin nasal replica. Using gentamicin as a marker, 168 experiments of aerosol deposition were performed with changes of particles size and breathing features under different nebulization conditions (100Hz acoustic airflow or not).
Results: The results of drug deposition clearly demonstrate that micrometric aerosol can be efficiently deposited into the maxillary sinuses. We also confirmed that 100 Hz acoustic airflow led to increase the deposition of drug into the maxillary sinuses by a factor 2-3 (e.g. 9mg/L vs. 4mg/L for the 3μm-particles). Finally a significant increase of drug intrasinus deposition was observed with the decreasing airflow rate.
Conclusion: Acoustic airflow, specific breathing patterns and aerosol size are the main parameters piloting drug intrasinus deposition. We emphasized in this study that the optimum deposition was obtained for micrometric particles with no breathing and 100Hz acoustic airflow. These fundamental data could improve benefits of drug deposition for the patients.